Powerful tool can map gene regulation at single-nucleotide resolution

Understanding how cells turn genes on and off is one of biology's most enduring mysteries. Now, a new technology developed by ...
Nature

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Human Rho GTPases (of which there are 22 members) comprise a main branch of the Ras superfamily of small GTPases and GDP/GTP-regulated molecular switches. Rho GTPases are activated by the direct ...
Hosted on MSN

The 3 Parts Of A Nucleotide Explained

Nucleotides are the building blocks of the two nucleic acids, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). As such, they are also the building blocks of you and every other lifeform on ...
InfoQ

InstaDeep Open-Sources Genomics AI Model Nucleotide Transformers

Unlock the full InfoQ experience by logging in! Stay updated with your favorite authors and topics, engage with content, and download exclusive resources. This article dives into the happens-before ...
The Scientist

An Overlooked Nucleotide Recycling Pathway Fuels Tumor Growth

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...
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Nucleotide database can improve microbe identification for science and medicine

Imagine creating a comprehensive, searchable index for a library containing hundreds of millions of books—a task that would take a single person a lifetime to complete. Now imagine discovering that ...

Structural variants reshape the yeast genotype–phenotype map

Université de Strasbourg and partners report that adding structural variants and small insertion–deletion mutations to single ...
Science Daily

Biosensor chip detects single nucleotide polymorphism wirelessly, with higher sensitivity

Scientists have developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and send the results in real time to an electronic device. The chip is at ...
ascopubs.org

In vitro assessment of the inflammatory breast cancer cell line SUM 149: Discovery of two single nucleotide polymorphisms in the RNase L gene.

Assessment of genetic predisposition to lymphedema. Background: Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer, accounting for 5% of breast cancers diagnosed annually in ...
Business Wire

ZHEN-AO GROUP Unveils TRIAL RESULTS: 5'-Nucleotide Reduces DNA Methylation Age by 3.08 Years

PARIS--(BUSINESS WIRE)--On August 24, 2025, the 23rd International Congress of Nutrition (ICN) convened in Paris, France, under the theme "Sustainable Food for Global Health." As the premier platform ...
ascopubs.org

Assessment of FcgRIIIA single nucleotide polymorphisms (SNPs) on the efficacy of IgG1 monoclonal antibodies (mAbs) in PANGEA study patients (pts) with advanced gastroesophageal ...

A phase Ib study of nivolumab plus trastuzumab with S-1/capecitabine plus oxaliplatin for HER2-positive advanced gastric cancer (Ni-HIGH study): Safety evaluation. Tumor response and growth rate of ...